KMID : 0604520160420010057
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Journal of the Society of Cosmetic Scientists of Korea 2016 Volume.42 No. 1 p.57 ~ p.64
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Inhibitory Effects of Dunaliella salina Extracts on Thermally-Induced Skin Aging
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Joo Ji-Hye
Seok Ji-Hyun Hong In-Kee Kim Nam-Kyoung Choi Eun-Mi
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Abstract
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Just like UV radiation, heat increases collagen degradation and accumulation of abnormal elastin fiber and this is termed thermal skin aging. Dunaliella salina (DS), a green alga, is known for its beta-carotene accumulation, having various applications in the health and nutritional products. However, the effects of DS on heat-induced skin aging remain unexplored. In this study, we performed anti-thermal aging tests of the ethanol extract of DS (DSE). We measured the cellular levels of type I procollagen and MMP-1 using ELISA in human dermal fibroblast cells after heat shock. DSE reduced the expression of MMP-1 protein and increased the expression of type I procollagen. In addition, DSE upregulated the mRNA expression of HSP47 reduced by heat shock, which is involved in collagen synthesis. Also, DSE reduced the expression of inflammation mediator (TGF-¥â, IL-12, etc). We demonstrate that DSE regulates the heat-induced solar elastosis through the regulation of tropoelastin and fibrillin-1, two major proteins of elastic fibers, and MMP-12 expression. These results suggest that DSE may be effective for preventing thermally induced skin aging.
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KEYWORD
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Dunaliella salina, thermal aging, heat shock, type I procollagen, solar elastosis
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